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Immunosenescence contributes to: Increased infection risk Slower recovery from illness Reduced vaccine responsiveness Chronic inflammation Greater susceptibility to age-related diseases At the same time , many older adults experience "inflammaging," a state of persistent low-grade inflammation that accelerates biological aging

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The individual peptide components are produced using controlled solid-phase peptide synthesis (SPPS) and purified through high-performance liquid chromatography (HPLC)

Persistent or repeated exposure to non-biodegradable or slowly cleared nanomaterials may therefore shift an initially adaptive microglial response toward chronic neuroinflammation, synaptic dysfunction, and neurodegeneration, particularly in aged or disease-susceptible brains (169)