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Results Long-term BDNF treatment improves excitatory synaptic current frequency and amplitude To investigate the ability of prolonged exposure to BDNF to regulate network dynamics and synaptic transmission, dissociated hippocampal cultures were treated for 4 days with 20 nM mature BDNF (named BDNF-treated cultures) and compared to untreated ones (named Controls)

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FoxOs inhibit mTORC1 and activate akt by inducing the expression of Sestrin3 and rictor