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[9] The Long R3 design pushes the same principle further: the Arg-for-Glu swap at position 3 removes a residue important for binding-protein contact, and the 13-residue N-terminal extension further perturbs the IGFBP interface

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As articular cartilage is an important structural and functional unit of the joint, cartilage degeneration and damage can cause impairment and loss of joint function in RA patients (94)

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