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Consequently, demand continues to grow among research professionals

While human clinical trials remain limited, the depth of animal research, consistency of positive findings across multiple study designs, and extensive community experience create a reasonable basis for therapeutic use

307 The JAK/STAT3 signaling pathway, one of the most important modes of STAT signaling, regulates cell function through cytokine-receptor interactions, activation of the JAK protein kinase, and phosphorylation of the STAT protein