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Journal of Diabetes & Metabolic Disorders, 21(1), 4349

They usually resemble in appearance the classical rash of a viral infection (many pink-to-red macules usually first appearing on the trunk and then spreading to the limbs and neck

The UPS is involved in protein quality control and removal of misfolded and aggregated proteins, and dysfunction of the UPS is implicated in the pathogenesis of neurodegenerative diseases (Popovic et al., 2014)