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For instance, -secretase inhibitors down-regulate levels of NICD and protect against ischemic stroke damages

More than 100,000 detectable peptide species elute in single shotgun proteomics runs but the majority is inaccessible to data-dependent LC-MS/MS

The presence of several key selenoproteins including GPXs, SELENOM, SELENOP, and SELENOS as well as SELENBP1 was reported for the intestine, Se status thus affecting gene expression, signaling pathways, and cellular functions in the small and large intestine as well as the gut microbiome composition (Speckmann and Steinbrenner, 2014)