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On the basis of impaired cushioning function, especially of large arteries, arterial stiffness causes (i) ISH, (ii) reduced coronary perfusion and increased afterload with resulting left ventricular diastolic dysfunction, and (iii) microvascular alterations with resulting end-organ damage (e.g., HFpEF, vascular dementia, and chronic kidney disease)

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Multi-omics integration may provide biomarkers and mechanistic basis for precise diagnosis and treatment of CFS