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The increased expression of Fis1 and Drp1 and decreased expression of fusion proteins (Opa1, Mfn1, and Mfn2) in addition to decreases in cAMP response element binding protein and PGC-1 have also been observed in aortic tissues of eNOS-null rodents (Miller et al., Enhanced iNOS gene expression and production in different tissues, especially in insulin-sensitive tissues, leads to peroxynitrite formation, causing nitrosative and oxidative stresses

The OD data were corrected for the OD of the blank group (wells without cell or LC treatment) and then normalized to the control group

Wang D, Kong X, Li Y, Qian W, Ma J, Wang D, Yu D, Zhong C

Amino.Acids 2008;35(2):419-423