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food and drug association FSP1: Ferroptosis suppressor protein 1 GCH1: GTP cyclohydrolase 1 Gly: Glycine GPX4: Glutathione peroxidase 4 GRT: Gene replacement therapy GSH: Glutathione reduced GSSG: Glutathione disulfide, oxidized His: Histidine IND: Investigational new drug iPSC: Induced pluripotent stem cell IRB: Institutional review board mGPX4: Mitochondrial GPX4 NAC: N-acetylcysteine NACA: N-acetylcysteine amide Nrf2: Nuclear factor erythroid 2-related factor 2 nGPX4: Nuclear GPX4 PHGPX: Phospholipid hydroperoxide glutathione peroxidase 4 PL: Phospholipid PL-OH: Phospholipid alcohol PL-OOH: Phospholipid hydroperoxide PL-PUFA: Phospholipid containing n-3 polyunsaturated fatty acids Pro: Proline ROS: Reactive oxygen species Sec: Selenocysteine SSMD: Sedaghatian type spondylometaphyseal dysplasia Tyr: Tyrosine Vit E: Vitamin E WES: Whole exome sequencing References Sedaghatian MR

Most studies are based on animal models and in vitro experiments, with small sample sizes that limit statistical power and make the findings susceptible to external objective factors, further affecting their reproducibility and representativeness