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Zhexiang Fan, Qian Qu and Ruosi Chen collected the clinical samples

2020 [cited 2024 Aug 2];12:2867

NCOA4-mediated FTH1 degradation is one explanation for the intracellular ferrous iron accumulation after ph-IOP, because knockdown of Ncoa4 inhibited FTH1 degradation, thereby alleviating ferrous iron accumulation

Unlike normal cells, which rely on oxidative phosphorylation, most cancers exhibit the Warburg effect, favoring aerobic glycolysis despite its low ATP yield (2 mol ATP/mol glucose) [35]