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Favism Exposure to the fava bean (Vicia fava, broad bean) is toxic and potentially fatal for some individuals, and this has been known, allegedly, since the time of Pythagoras

10.1016/j.ejmech.2022.115015 170 GuanX.LiZ.ZhuS.ChengM.JuY.RenL.et al (2021)

Here, we present compelling results demonstrating a functional connection between altered TrkB signalling in iSPNs and changes in glutathione metabolism, particularly the enzyme GSTO2, at the pre-symptomatic stage, causing an early increase in DA followed by progressive degeneration and the onset of hyperkinetic symptoms

[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Iso T, Suzuki T, Baird L, Yamamoto M