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This can be explained by the fact, that superoxide radical is necessary to achieve redox cycling of metal ions (Halliwell and Gutteridge 1990)

The impairment of mitochondrial function caused by linoleic acid, a fatty acid that accumulates in NAFLD, leads to greater oxidative damage than that caused by other free fatty acids, such as palmitic acid, and contributes to the selective depletion of intrahepatic CD4 + T lymphocytes

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For small metabolites, such as glycolytic intermediates and amino acids, IsoNet can also connect them through isotopologue pattern similarity networking (see examples in Fig