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Springer, Cham, pp 105122

e-GST level in transplant patients e-GST level was determined in 153 kidney transplant patients from cadaver and 16 kidney transplant patients from living donors, at least 3 months from the transplantation

Multivariate analysis showed that male (hazard ratio [HR] 2.27, 95%CI 1.17-4.39, P=0.013), platelet count 8.3x10 4 /l (HR 2.11, 95%CI 1.06-4.19, P=0.032) and presence of EV before BRTO (HR 2.36, 95%CI 1.06-5.27, P=0.029) were significant independent risk factors of EV worsening

Most therapeutic interventions remain in preclinical development, with clinical translation hindered by two key barriers: The lack of validated biomarkers for patient stratification and incomplete elucidation of synergistic combination mechanisms