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This analysis identified six cysteine residuesCys239, Cys240, Cys246, Cys404, Cys487, and Cys491as potential sites of itaconation (Supplementary Fig

doi: 10.1159/000335560 133

Several studies have exposed that the long-term use of MPH induces the DA neuron loss and microglia activation causing an increase in pro-inflammatory markers TNF and IL-1, among others, resulting in the activation of neuroinflammation and triggering a neurodegenerative process [192, 193]