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Progesterone signals by binding to progesterone receptors, which have two isoforms (A and B) that exhibit tissue-specific expression and functions (123)

In human breast cancer cell lines, the glutamine transporter inhibitor V-9302 upregulated PD-1 expression and induced immune escape [78]

The experimental findings showed that HT inhibited the expression of Tfr1, GPX4, and SLC7A11 in HCT116 and SW480 cells, indicating that HT may induce ferroptosis in these cells