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Food and Drug Administration) Dietary deficiency of vitamin B 12 occurring in strict vegetarians and in their breastfed infants (isolated vitamin B 12 deficiency is very rare) Malabsorption of vitamin B 12 resulting from damage to the stomach, where intrinsic factor is secreted, or damage to the ileum, where intrinsic factor facilitates vitamin B 12 absorption

For example, injectable pyridoxine solutions may contain aluminum as a trace impurity, and with prolonged use in patients with renal impairment (especially premature neonates with immature kidneys) there is a risk of aluminum accumulation and toxicity

(2018), which may partially address limited blood supply