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Key Points IGF1R is expressed in a large range of tumors and is crucial for tumor transformation and survival of malignant cells IGF1R signaling interferes with numerous growth factors and receptors pathways such as VEGF and EGFR, and IGF1R signaling has been found to correlate with resistance to both anti-EGFR therapies and those that target HER2 Several monoclonal antibodies and smallmolecular inhibitors are being tested in preclinical and clinical studies

Powder: Offers maximum flexibility in dosing, though the natural sulfur content often makes the taste take some getting used to

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