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The guiltiest heavy metal

Biomolecules 9 , 79 (2019)

doi:10.1002/anie.201210359 44

Interventions such as the antioxidant NAC or the inhibition of MAPK8/JNK activity have been demonstrated to mitigate ROS-induced parthanatos in glioma cells [156], suggesting that MAPK8 activation contributes to parthanatos by enhancing intracellular ROS levels