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CAT is another antioxidant enzyme the activity of which can be affected by Pb, because the latter inhibits the synthesis of heme, which is a basic component in the structure of this antioxidant enzyme (34)

Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains

Studies indicate that cells will make a glycolytic switch when NAD + demand is high and exceeds ATP demand, therefore skewing the NAD + use for this pathway 341