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2.9.2 Animal models Female Balb/c mice (45 weeks) were purchased from Shanghai Laboratory Animal Center (SLAC, Shanghai, China) and bred in a sterilized, specific pathogen-free (SPF) Lab of Tongji University

I regularly consume any of the following substances or medications: Acetaminophen (Tylenol) Acid-blocking drugs (Tagamet, Zantac, Pepcid, Prilosec, Prevacid) Hormone-modulating medications in pills, patches, or creams (the birth control pill, estrogen, progesterone, prostate medication) Ibuprofen or naproxen Medications for recurrent headaches, allergy symptoms, nausea, diarrhea, or indigestion 18

Sensitivity or Allergies to B12 or Its Components: Some individuals may have an allergic reaction to the preservatives or additives in B12 injections, especially those with known sensitivities to certain medications or substances

6d), but did not induce the mito-UPR marker hsp-6 (Supplementary Fig