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Oversecretion of aldosterone ( hyperaldosteronism ) by the adrenal glands can also interfere with water and sodium retention by the kidney and has been associated with treatment-resistant hypertension (Calhoun 2013

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Of note, oxidative protein folding is still possible in hypoxia because ERO1, which transfers electrons to oxygen, can function under low oxygen tension owing to its very low K m for oxygen 30

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