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Description

Prompt parenteral administration of vitamin B12 prevents progression of neurologic damage

June 23, 2023

NNMT is a metabolic enzyme that regulates cellular energy and methylation potential by preventing NAM (Nicotinamide) from participating in the NAD+ Salvage Pathway and converting back into NAD+

In addition to MNAM and NNMTi, three new NAM analog inhibitors were reported for the treatment of MetS-related disorders in animal models: JBSNF-000088 ( JBSNF-000265 (Ruf et al., 2018), and JBSNF-000028 (Ruf et al., 2022)