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Coenzyme Q 10 supplementation was well tolerated at all doses and resulted in a slower deterioration of function in Parkinson's disease patients in the group taking 1,200 mg/day

More specifically, M1 macrophages rely on glycolysis and accumulation of succinate from the TCA cycle to stabilize HIF1, which in turn activates the transcription of glycolytic genes sustaining glycolytic metabolism in M1 macrophages (78)