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111 Furthermore, the hyperlactylation of IKAROS family zinc-finger 1 (Ikzf1) at lysine 164 downregulates the expression of interleukin-2 (IL-2) and interleukin-4 (IL-4) while simultaneously enhancing the expression of Toll-like receptor 4 (Tlr4) and Runt-related transcription factor 1 (Runx1)

Elevated LPS from gram-negative bacterial overgrowth activates TLR4-mediated innate immunity, triggering further IL-1 release (Levy et al., 2017)

(4) The researchers reported, On days 6, 10, and 13, tripeptide-copper complex-treated wounds contained significantly lower concentrations of TNF-alpha and MMP-2 and MMP-9 than control wounds. Tumor necrosis factor-alpha (TNF-alpha), a cytokine involved in systemic inflammation, along with matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) enzymes that break down extracellular matrix proteins might potentially influence both the inflammatory processes and the remodeling of tissues