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Because RP is a chronic condition, the development of a minimally invasive therapeutic that reduces frequency of application with local administration is appealing to reduce risk of non-adherence

In another aspect of the invention, a method of targeted drug delivery of an effective amount of an agent, or a pharmaceutical acceptable carrier comprising an agent, to a target site that is protected by a specific blood-tissue barriers like e.g., the CNS, the blood-brain barrier (BBB), the retina and the testes, is provided wherein: a) the agent or the pharmaceutical acceptable carrier is conjugated to a ligand, that facilitates the specific binding to and internalization by an internalizing GSH uptake receptor of the target site, thereby forming the conjugate as defined above

In this surgery the ball of the hip joint is removed, leaving muscles to act as the joint

3a), which is well consistent with the tendency of transcriptome data from plants in response to wounding, namely, more transcripts are upregulated than downregulated 27,28