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Spedding, M

While a low-carbohydrate high-fat diet has been used in traditional medicine for about a 100 years, for diabetics since before insulin was developed and for seizure control, the natural lifestyle of the earliest humans relied on this diet to generate large quantities of metabolic energy from the oxidation of fatty acids to develop larger brains and bodies, prevent and reduce disease risk, extend longevity, in addition to other benefits (66)

"Glutamine and glutamate: Nonessential or essential amino acids?"

In mouse and cell models of amyotrophic lateral sclerosis (ALS), IGF1 also strongly protects mitochondria from apoptosis and upregulates mitophagy, as evidenced by a decrease in the p62 level and an increase in the LC3-II level (Wen et al., 2019)