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Addressing these questions will require time-resolved ubiquitin proteomics and tissue-specific in vivo loss-of-function studies across circadian timepoints to understand how the UPS both encodes and responds to circadian signals at the molecular level

Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism

Cells were centrifuged, resuspended in HBSS with 15 mM HEPES, and sequentially passed through 100 m and 20 m mesh filters to isolate cell clusters between 20 and 100 m