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See representative reviews and trials for context: a randomized trial protocol and review, a review summarizing silymarin's metabolic effects (ScienceDirect review), and recent supplementation analyses reporting trial outcomes

Since most studies did not include depression/anxiety patients of the same severity, it was difficult to conduct subgroup analysis based on baseline disease severity

In the afferent direction, area postrema is dense with mast cells (Figure 1) in order for signal to be detected ( Figure 1 Because neuroinflammation can affect normal function and structure, even methods that do not directly measure neuroinflammation (e.g., fMRI and structural MR) can be clarifying if their focus is on neuroinflammation-relevant brain circuits and structures

doi: 10.1038/nprot.2006.378 34 KarpuzogluEFenauxJBPhillipsRALengiAJElvingerFAnsar AhmedS