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The binding to CD20 enables rituximab to deplete subpopulations of B lymphocytes by way of cell-mediation, complement-dependent cytotoxicity, and the promotion of apoptosis and growth arrest

Increased monitoring may be required to identify and minimize the toxicity of warfarin, phenytoin, theophylline, or sulfonylureas when an azole antifungal is co-administered

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Consultation with a doctor or pharmacist is particularly important when taking the following: Liver-metabolised medications (CYP substrates) Blood sugar-lowering medications (antidiabetics) Cholesterol-lowering medications (statins) Oral contraceptives Protease inhibitors (e.g