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Endocrinology 158 , 22552268 (2017)

Chen LM, Bao CH, Wu Y, Liang SH, Wang D, Wu LY, et al

The absorption of B12 depends on a protein produced in the stomach which decreased with age, therefore even meat eaters can be deficient in this vitamin

Its pathogenesis primarily involves immune dysregulation, including breakdown of immune tolerance, alterations in the immune microenvironment, and dysregulation of T cell subsets (158, 159)