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The copper is not freely available to catalyze reactions with other species at physiological pH

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Giredestrant increases PUFA-containing phospholipids at the expense of MUFA-phospholipids We investigated the mechanism of GPX4 dependency in giredestrant treated cells, with transcriptional profiling of MCF-7 cells that had been transduced with either control sgRNAs (targeting olfactory receptor genes OR51Q1 and OR5M9), or GPX4 sgRNAs