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Structural Modification The modification involves deletion of the first three N-terminal amino acids (glycine-proline-glutamate) from the 70-amino acid native IGF-1 sequence, creating a 67-amino acid variant with profound implications for receptor binding, bioavailability, and biological activity

Alimta (pemetrexed disodium) is a chemotherapy drug classified as an antifolate, meaning it works by interfering with the growth of cancer cells

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