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The coordinated nature of these pathway disruptions is particularly significant, as CSCs often demonstrate remarkable plasticity and can maintain their stem-like properties through compensatory activation of alternative signaling routes when individual pathways are targeted in isolation

2021;21(2):e26e35

The reason for these aforementioned side effects may be correlated with the physiological function of HGF/c-Met in many organs, including cytoprotective, regenerative, and reduction of apoptosis after injury (Birchmeier et al., 2003)