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These findings are documented but derive predominantly from animal studies and should be interpreted accordingly

NOX2-derived ROS play a crucial role in modulating the redox microenvironment and influencing antigenic peptide stability, ultimately enhancing T-cell activation (69)

Modern studies have reported that the protein-free Guang-Pheretima decoction (PF-GPD) can inhibit the release of inflammatory factors IL-1 and IL-6, regulate the homeostasis of microcirculation, and play an important role in the intervention of HACE pathology (Sun et al., 2019)