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Consistency over weeks and months matters more than intensity on any single day

Interestingly, only one case of Reyes syndrome associated with Kawasaki disease has ever been reported, and only in the Japanese literature, giving an incidence of 0.005%

A study of the plasma pharmacokinetics of R-(+)-lipoic acid revealed that maximum concentrations were reached within ~30 min of administration and had a short half life when administered as sodium R-(+)-lipoate to healthy human subjects