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Further, our findings revealed observably decreased patterns of the NLRP3/GSDMD pathway-related proteins and inflammatory factors, reduced Iba-1 + NLRP3+ and Iba-1 + GSDMD-N+ cells and reduced Racine score, ameliorated learning and memory abilities, alleviated tissue and neuronal injury in the hippocampal CA1 area, as well as increased number of NSE-positive cells in mice following the NLRP3/GSDMD pathway suppression

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Those signals matter more in 2026 than they did before the 2025 vendor consolidation