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Together, these findings provide compelling evidence that oxidative stress plays a critical role in the pathophysiology of depression and may represent both a biomarker of disease severity and a potential target for therapeutic intervention through modulation of antioxidant defenses (3537)

This downregulation turns out to be responsible for low sugar uptake and in turn for BBB breakdown, worsening AD cerebrovascular degeneration, neuropathology and cognitive functions (Winkler et al., 2015)