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Moreover, DHA increased CREB phosphorylation and BDNF levels and attenuated neuroinflammation and oxidative stress, reflected by lower levels of IBA-1, IL-1, and IL-6 and increased levels of SOD1 and Nrf2

Dichloroacetate (DCA): This small molecule inhibits pyruvate dehydrogenase kinase, promoting pyruvate entry into mitochondria and favoring OXPHOS over glycolysis