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10.1016/j.transci.2023.103755 78 RinalducciS.FerruE.BlasiB.TurriniF.ZollaL

These observations highlight the importance of incorporating dynamic and biophysical conditions in COPD research to better understand the complex interactions between cell types and mechanical forces in the lung

In additional, our controls were not given a placebo

Later experiments have found that adding high doses of copper can increase reactive oxygen species and protein carbonylation levels, decrease glutathione levels and SOD enzyme activity, leading to depolarization of mitochondrial membrane potential, the release of cytochrome c, elevated levels of active caspase-9 and caspase-3, increased levels of Bcl2-antagonist/killer 1 (Bak1) and Bcl2-associated X protein (Bax), and decreased levels of B-cell lymphoma 2 (Bcl2), ultimately resulting in cell apoptosis (134)