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Description

2729 Currently, three major signaling proteins including c-Jun N-terminal kinase (JNK), Nrf2, and p53 have been found to be involved in mitochondrial oxidative stress

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The therapeutic efficacy of Ebselen has been studied in experimental diabetic models (de Haan and Cooper 2011)

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This contrasts with the heterogeneous toxicity of GPX4 inhibitors, which have previously shown resistance in certain NE subtypes 40

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