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Moreover, the pyruvate dehydrogenase kinase 4 (PDK4), located in the inner membrane of mitochondria, mediates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acids synthesis, which facilitates lipid peroxidation-dependent ferroptotic death [107]

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Dopamine dysregulation has also been implicated in the development of depressive symptoms, and the loss of estrogens influence on dopamine receptors can exacerbate this [52]

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