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Key gaps include: No large-scale randomised controlled trials in humans the evidence basis for clinical use is extrapolated from animal data and small pilot studies No long-term safety data effects beyond 1216 weeks are not well characterised Variable results in human sleep trials some early human studies showed modest or inconsistent effects on sleep architecture compared to animal data, suggesting the translation may not be linear No FDA approval DSIP is not approved for any therapeutic use in the United States Stability concerns DSIP degrades relatively quickly in circulation

Kefir also modulates immune responses and intestinal microbiota, contributing to its anticancer effects

Research on vaginal microbiota and its functions is crucial because it is closely linked to various gynecological cancers (Liu et al., 2020)

Statistical Analysis The data analyzed in this study included growth performance (body weight, average daily gain), reproductive parameters, milk production (yield, composition), blood biochemical profiles, hormonal concentrations (T3, T4, P4, E2), and immunoglobulin levels in colostrum (IgA, IgM, IgG)