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Le stress, l'excs d'oestrognes (un problme malheureusement trop frquent dans le syndrome prmenstruel et trs peu pris en compte par les mdecins actuels) ou encore l'exposition aux mtaux lourds (les vaccins, cadmium du tabac, gros poissons pollus, etc.) - pour ne citer que ces facteurs environnementaux - peuvent inhiber l'action de ce gne GSTM1

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Wnt ligands bind to Frizzled receptors on the cell surface, resulting in the increased stability of cytoplasmic -catenin, and its subsequent translocation into the nucleus, where it activates the transcription of MITF by interplay with lymphoid enhancer-binding factor 1 (LEF1)/T-cell factor (LEF1/TCF) (26)