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History of dietary treatment: Guelpa & Marie first report of intermittent fasting for epilepsy in 1911

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A phase II trial for RAIR-DTC reported a 58% disease control rate, with a median PFS of 9 months and OS of 18 months [116]

This connection emphasizes the critical role of the gut-liver-immune axis in the disease process and identifies it as a valuable focus for novel treatments (57)