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Curr Protein Pept Sci 2017;18:656-76

9 The structure of HK1 is complex: it encompasses 25 exons that, by tissue-specific transcription, generate multiple transcripts through alternative splicing of different 5 exons

24 Numerous studies have shown that the dysregulation of TGF-1/Smad represents an important pathogenic pathway in various tissue fibrogenesis, including lung, liver and kidney fibrosis