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With respect to the effect of azithromycin on neutrophils, Bystrzycka et al

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doi: 10.1016/j.bbadis.2023.166995 51 WangYEshwaranRBeckSCHammesHPWielandTFengY

The answer, put simply, is cellular senescence: FOXO4 can interact with p53, which is involved in the regulation of multiple target genes and controls a wide range of cellular processes, including metabolic adaptation, DNA repair, cell cycle arrest, apoptosis, and senescence