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Cell Death and Disease DOI:10.1038/s41419-026-09108-y Abstract Acid ceramidase modulates the lipid profile and exacerbates sensitivity to ferroptosis in WI-38 replicative senescent cells Cellular senescence, a complex biological process characterized by irreversible cell cycle arrest and the senescence-associated secretory phenotype, has emerged as a critical target for therapeutic development for age-related diseases

Research has shown that the serum Fn concentration is directly proportional to the severity of menstrual dysfunction, suggesting that the iron retention effect of chronic oligomenorrhea may be associated with increased iron storage in some PCOS patients (140)

63 Furthermore, BCAT 1 is selectively upregulated in isocitrate dehydrogenase (IDH) wild-type (WT) GBM, and -ketoglutarate (-KG) mediates cell death in BCAT 1-deficient IDH WT GBM

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