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S4E, F, depletion of GGCT in HCC and PCa cells led to G 2 /M phase arrest and decreased CCNB1 and CDK1 and p-CDK1 protein levels

In some cases, vacuolar peptidases may cleave the glutamate and glycine of the original glutathione molecule, leaving the cysteinyl conjugate (cysteine-X) which may need further processing in Phase III reactions, such as incorporation into cell wall material