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Ryan GM, Kaminskas LM, Porter CJ

doi:10.1016/S0140-6736(21)01751-7 [2] Carvas AO, Leuthardt A, Kulka P, et al

Drug-induced liver toxicity accounts for nearly half the cases of acute liver failure in adults over age 50 in the United States [3] and most have been associated with the generation of reactive metabolites, which are primarily detoxified via glutathione conjugation [4]