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Recently, it has been demonstrated that PGC-1 is located within mitochondria, where it co-localizes within the D-loop of mtDNA with mitochondrial transcription factor A (TFAM) (49)

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However, since therapeutic modalities targeting some metabolic targets have not yet been effectively developed and clinically applied, in-depth investigations of the relationship between FA metabolic reprogramming and the development of CCA, as well as the discovery of more therapeutically valuable potential targets, have become urgently needed